2023
Langbroek GB, Stor MLE, Janssen V, de Haan A, Horbach SER, Graupera M, van Noesel CJM, van der Horst CMAM, Wolkerstorfer A, Huveneers S. Characterization of patient-derived GNAQ mutated endothelial cells from capillary malformations. JOURNAL OF INVESTIGATIVE DERMATOLOGY, in press, 2023.
Luik AL, Hannocks MJ, Loismann S, Kapupara K, Cerina M, van der Stoel M, Tsytsyura Y, Glyvuk N, Nordenvall C, Klingauf J, Huveneers S, Meuth S, Jakobsson L, Sorokin L. Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication. MATRIX BIOLOGY 121:56-73, 2023.
Buikhuisen JY, Gomez Barila PM, Cameron K, Suijkerbuijk SJE, Lieftink C, di Franco S, Krotenberg Garcia A, Uceda Castro R, Lenos KJ, Nijman LE, Torang A, Longobardi C, de Jong JH, Dekker D, Stassi G, Vermeulen L, Beijersbergen RL, van Rheenen J, Huveneers S, Medema JP. Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer. JOURNAL OF EXPERIMENTAL & CLINICAL RESEARCH 42(1):56, 2023.
van der Stoel MM#, Kotini MP#, Schoon RM, Affolter M, Belting HG*, Huveneers S*. Vinculin strengthens the endothelial barrier during vascular development. VASCCULAR BIOLOGY, 5(1):e220012, 2023. # Shared first authors, * Shared last authors.
2022
Mieremet A#, van der Stoel M#, Li S, Coskun E, van Krimpen T, Huveneers S*, de Waard V*. Endothelial dysfunction in Marfan syndrome mice is restored by resveratrol. SCIENTIFIC REPORTS, 12(1):22504, 2022. # Shared first authors, * Shared last authors.
Hooglugt A, Klatt O, Huveneers S. Vascular stiffening and endothelial dysfunction in atherosclerosis. CURRENT OPINION IN LIPIDOLOGY, 33(6):353-363, 2022.
Nitz K, Lacy M, Bianchini M, Wichapong K, Kücükgöze IA, Bonfiglio CA, Migheli R, Wu Y, Burger C, Li Y, Forné I, Ammar C, Janjic A, Mohanta S, Duchene J, Heemskerk JWM, Megens RTA, Schwedhelm E, Huveneers S, Lygate CA, Santovito D, Zimmer R, Imhof A, Weber C, Lutgens E, Atzler D. The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. CIRCULATION RESEARCH, 131(8):701-712, 2022.
Kotini MP#, van der Stoel MM#, Yin J, Han MK, Kirchmaier B, de Rooij J, Affolter M, Huveneers S*, HG Belting*. Vinculin controls endothelial cell junction dynamics during vascular lumen formation. CELL REPORTS, 39(2): 110658, 2022. # Shared first authors, * Shared last authors.
2021
Goedhart M, Slot E, Pascutti MF, Geerman S, Rademakers T, Nota B, Huveneers S, Buul JDV, MacNamara KC, Voermans C, Nolte MA. Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen. CELLS, 11(1):55, 2021.
Duong CN, Brückner R, Schmitt M, Nottebaum AF, Braun L, Zu Brickwedde MM, Ipe U, Vom Bruch H, Schöler HR, Trapani G, Trappmann B, Ebrahimkutty MP, Huveneers S, Rooij J, Ishiyama N, Ikura M, Vestweber D. Force-induced changes of α-catenin conformation stabilize vascular junctions independent of vinculin. JOURNAL OF CELL SCIENCE jcs.259012, 2021.
Kluza E, Beldman TJ, Shami A, Scholl ER, Malinova TS, Grootemaat AE, van der Wel NN, Gonçalves I, Huveneers S, Mulder WJM, Lutgens E. Diverse ultrastructural landscape of atherosclerotic endothelium. ATHEROSCLEROSIS 339:35-45, 2021.
Arts JJG, Mahlandt EK, Schimmel L, Grönloh MLB, van der Niet S, Klein BJAM, Fernandez-Borja M, van Geemen D, Huveneers S, van Rijssel J, Goedhart J, van Buul JD. Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling. FRONT IMMUNOL 12:667213, 2021.
Malinova TS, Angulo-Urarte A, Nüchel J, Tauber M, van der Stoel MM, Janssen V, de Haan A, Groenen AG, Tebbens M, Graupera M, Plomann M, Huveneers S. A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. NATURE COMMUNICATIONS, 12(1):2610, 2021. [Paper]
Sluiter TJ, van Buul JD, Huveneers S, Quax PHA, de Vries MR. Endothelial barrier function and leukocyte transmigration in atherosclerosis. BIOMEDICINES, 9(4):328, 2021.
Hooglugt A, van der Stoel MM, Boon RA, Huveneers S. Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature. FRONT ONCOL, 10:612802, 2021.
2020
Jones EAV, Graupera M, van Buul JD, Huveneers S. Editorial: Endothelial Dynamics in Health and Disease. FRONT PHYSIOL, 11:611117, 2020.
Rademakers T, Goedhart M, Hoogenboezem M, García Ponce A, van Rijssel J, Samus M, Schnoor M, Butz S, Huveneers S, Vestweber D, Nolte MA, Voermans C, van Buul JD. Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium. HAEMATOLOGICA, 105(12):2746-2756, 2020.
van der Wijk AE, Georgakopoulou T, Majolée J, van Bezu JSM, van der Stoel MM, van Het Hof BJ, de Vries HE, Huveneers S, Hordijk PL, Bakker ENTP, van Bavel E. Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain. ACTA NEUROPATHOL COMMUN, 8(1):195, 2020.
Poels K, van Leent MMT, Boutros C, Tissot H, Roy S, Meerwaldt AE, Toner YCA, Reiche ME, Kusters PJH, Malinova T, Huveneers S, Kaufman AE, Mani V, Fayad ZA, de Winther MPJ, Marabelle A, Mulder WJM, Robert C, Seijkens TTP, Lutgens E. Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis. JACC CARDIOONCOLOGY, 2(4) 599–610, 2020.
Poels K, van Leent MMT, Reiche ME, Kusters PJH, Huveneers S, de Winther MPJ, Mulder WJM, Lutgens E, Seijkens TTP. Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice. CELLS, 9(9):1987, 2020.
Tan JME#, van der Stoel MM#, van den Berg M, van Loon NM, Moeton M, Scholl E, van der Wel NN, Kovačević I, Hordijk PL, Loregger A, Huveneers S*, Zelcer N*. The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting. CELL REPORTS. 32(5):107944, 2020. # Shared first authors; * Shared last authors. [Paper]
Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon HB, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. COMMUNICATIONS BIOLOGY, 3(1):265, 2020. [Paper]
Angulo-Urarte A, van der Wal T, Huveneers S. Cell-cell junctions as sensors and transducers of mechanical forces. BBA BIOMEMBRANES 2020, 862(9):183316. [Paper]
Botros L, Pronk MCA, Juschten J, Liddle J, Morsing SKSH, van Buul JD, Bates RH, Tuinman PR, van Bezu JSM, Huveneers S, Bogaard HJ, van Hinsbergh VWM, Hordijk PL, Aman J. Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity. JOURNAL OF CELL SCIENCE 2020, Mar 20. pii: jcs.240077. [Paper]
van der Stoel M, Schimmel L, Nawaz K, van Stalborch AM, de Haan A, Klaus-Bergmann A, Valent ET, Koenis DS, van Nieuw Amerongen GP, de Vries CJ, de Waard V, Gloerich M, van Buul JD, Huveneers S. DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis. JOURNAL OF CELL SCIENCE 2020, Feb 12; 133(3). pii: jcs 239947 [Paper] [Research Highlight] [First person interview] [Cover]
Bebelman MP, Bun P, Huveneers S, van Niel G, Pegtel DM, Verweij FJ. Real-time imaging of multivesicular body-plasma membrane fusion to quantify exosome release from single cells. NATURE PROTOCOLS 2020, Jan; 15(1):102-121 [Paper]
2019
Brezovjakova H, Tomlinson C, Mohd Naim N, Swiatlowska P, Erasmus JE, Huveneers S, Gorelik J, Bruche S, Braga VM. Junction Mapper is a novel computer vision tool to decipher cell-cell contact phenotypes. ELIFE. 2019 Dec 3;8. pii: e45413. [Paper]
Dorland YL, Cornelissen AS, Kuijk C, Tol S, Hoogenboezem M, van Buul JD, Nolte MA, Voermans C, Huveneers S. Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression. SCIENTIFIC REPORTS, 2019, 9(1):14401. [Paper]
Beldman TJ#, Malinova TS#, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen CPAA, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E. Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy. ACS NANO. 2019; 13(12): 13759-13774.[Pubmed]
Goedhart M, Gessel S, van der Voort R, Slot E, Lucas B, Gielen E, Hoogenboezem M, Rademakers T, Geerman S, van Buul JD, Huveneers S, Dolstra H, Anderson G, Voermans C, Nolte MA. CXCR4, but not CXCR3, drives CD8+ T-cell entry into and migration through the murine bone marrow. EUR J IMMUNOL. 2019 Apr;49(4):576-589. [Pubmed]
Malinova TS, Huveneers S. Opening the vascular gate. NAT NANOTECHNOLOGY 2019; 14(3):195-196. [Paper]
2018
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V, Milà-Guasch M, Millan J, Wiesner C, Serra H, Muixi L, Casanovas O, Viñals F, Affolter M, Gerhardt H, Huveneers S, Belting HG, Cutillas PR, Graupera M. Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility. NAT COMMUN 2018;9 (1):4826 [PubMed]
Schimmel L, van der Stoel M, Rianna C, van Stalborch AM, de Ligt A, Hoogenboezem M, Tol S, van Rijssel J, Szulcek R, Bogaard HJ, Hofmann P, Boon R, Radmacher M, de Waard V, Huveneers S, van Buul JD. Stiffness-induced endothelial DLC-1 expression forces leukocyte spreading through stabilization of the ICAM-1 adhesome. CELL REPORTS 2018; 24: 3115-3124. [Paper]
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Evers-van Gogh IJ, van den Bossche J, Speijer D, Kim Y, Wessels L, Zelcer N, Zwart W, Kalkhoven E, de Vries CJ. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. CELL REPORTS 2018; 24 (8):2127-2140.e7 [PubMed]
Goedhart M, Cornelissen AS, Kuijk C, Geerman S, Kleijer M, van Buul JD, Huveneers S, Raaijmakers MH, Young HA, Wolkers MC, Voermans C, Nolte MA. Interferon-gamma impairs maintenance and alters hematopoietic support of bone marrow mesenchymal stromal cells. STEM CELLS DEV 2018; May 1;27(9):579-589 [PubMed]
Malinova TS, Huveneers S. Sensing of cytoskeletal forces by asymmetric adherens junctions. TRENDS CELL BIOL 2018; Apr; 28(4):328-341 [PubMed]
2017
Dorland YL, Huveneers S. Cell-cell junctional mechanotransduction in endothelial remodeling. CELL MOL LIFE SCI 2017; 74(2):279-292 [PubMed]
2016
Dorland YL*, Malinova TS*, van Stalborch AMD, Grieve AG, van Geemen D, Jansen NS, de Kreuk BJ, Nawaz K, Kole J, Geerts D, Musters RJP, de Rooij J, Hordijk PL, Huveneers S. The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions. NAT COMMUN 2016;7:12210 [PubMed] *equal contribution
Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, van Unen J, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD. F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. NAT COMMUN 2016;7:10493[PubMed]
2015
Fraccaroli A, Pitter B, Taha AA, Seebach J, Huveneers S, Kirsch J, Casaroli-Marano RP, Zahler S, Pohl U, Gerhardt H, Schnittler HJ, Montanez E. Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions. CIRC RES 2015;117 (1):29-40[PubMed]
Hamers AAJ, van Dam L, Teixeira Duarte JM, Vos M, Marinković G, van Tiel CM, Meijer SL, van Stalborch AM, Huveneers S, te Velde AA, de Jonge WJ, de Vries CJM. Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages. PLOS ONE 2015;10 (8):e0133598 [PubMed]
Huveneers S, Daemen MJAP, Hordijk PL. Between Rho(k) and a hard place: the relation between vessel wall stiffness, endothelial contractility, and cardiovascular disease. CIRC RES 2015;116 (5):895-908 [PubMed]
Oldenburg J, van der Krogt G, Twiss F, Bongaarts A, Habani Y, Slotman JA, Houtsmuller A, Huveneers S, de Rooij J. VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module. SCI REP-UK 2015;5:17225 [PubMed]
Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TWJ Jr, Yin T, Wu Y, Huveneers S, van Buul JD. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1. J CELL SCI 2015;128 (16):3041-3054[PubMed]
2014
Hamers AAJ, Uleman S, van Tiel CM, Kruijswijk D, van Stalborch AM, Huveneers S, de Vries CJM, van 't Veer C. Limited role of nuclear receptor Nur77 in Escherichia coli-induced peritonitis. INFECT IMMUN 2014;82 (1):253-264[PubMed]
van Buul JD, Geerts D, Huveneers S. Rho GAPs and GEFs: controling switches in endothelial cell adhesion. CELL ADHES MIGR 2014;8 (2):108-124 [PubMed]
van Geemen D, Smeets MWJ, van Stalborch AMD, Woerdeman LAE, Daemen MJAP, Hordijk PL, Huveneers S. F-actin-anchored focal adhesions distinguish endothelial phenotypes of human arteries and veins. ARTERIOSCL THROM VAS 2014;34 (9):2059-2067 [PubMed]
2013
Huveneers S, de Rooij J. Mechanosensitive systems at the cadherin-F-actin interface. J CELL SCI 2013;126 (Part 2):403-413 [PubMed]
2012
Aman J, van Bezu J, Damanafshan A, Huveneers S, Eringa EC, Vogel SM, Groeneveld ABJ, Vonk Noordegraaf A, van Hinsbergh VWM, van Nieuw Amerongen GP. Effective treatment of edema and endothelial barrier dysfunction with imatinib. CIRCULATION 2012;126 (23):2728-2738 [PubMed]
Huveneers S, Oldenburg J, Spanjaard E, van der Krogt G, Grigoriev I, Akhmanova A, Rehmann H, de Rooij J. Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling. J CELL BIOL 2012;196 (5):641-652 [PubMed]
Twiss F, Le Duc Q, van der Horst S, Tabdili H, van der Krogt G, Wang N, Rehmann H, Huveneers S, Leckband DE, de Rooij J. Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.BIOL OPEN 2012;1 (11):1128-1140 [PubMed]
2011
Pannekoek WJ, van Dijk JJG, Chan OYA, Huveneers S, Linnemann JR, Spanjaard E, Brouwer PM, van der Meer AJ, Zwartkruis FJT, Rehmann H, de Rooij J, Bos JL. Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.CELL SIGNAL 2011;23 (12):2056-2064 [PubMed]
2010
Huveneers S, Danen EHJ. The interaction of SRC kinase with beta3 integrin tails: a potential therapeutic target in thrombosis and cancer. SCI WORLD J 2010;10:1100-1105 [PubMed]
2009
Huveneers S, Danen EHJ. Adhesion signaling - crosstalk between integrins, Src and Rho. J CELL SCI 2009;122 (Part 8):1059-1069 [PubMed]
Puigvert JC, Huveneers S, Fredriksson L, op het Veld M, van de Water B, Danen EHJ. Cross-talk between integrins and oncogenes modulates chemosensitivity. MOL PHARMACOL 2009;75 (4):947-955 [PubMed]
2008
Huveneers S, Arslan S, van de Water B, Sonnenberg A, Danen EHJ. Integrins uncouple Src-induced morphological and oncogenic transformation. J BIOL CHEM 2008;283 (19):13243-13251 [PubMed]
Huveneers S, Truong H, Fässler R, Sonnenberg A, Danen EHJ. Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J CELL SCI 2008;121 (Part 15):2452-2462 [PubMed]
2007
Huveneers S, Truong H, Danen HJ. Integrins: signaling, disease, and therapy.INT J RADIAT BIOL 2007;83 (11-12):743-751 [PubMed]
Huveneers S, van den Bout I, Sonneveld P, Sancho A, Sonnenberg A, Danen EHJ. Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src. CANCER RES 2007;67 (6):2693-2700 [PubMed]
van den Bout I, Truong HH, Huveneers S, Kuikman I, Danen EHJ, Sonnenberg A. The regulation of MacMARCKS expression by integrin beta3. EXP CELL RES 2007;313 (6):1260-1269 [PubMed]
2005
Danen EHJ, van Rheenen J, Franken W, Huveneers S, Sonneveld P, Jalink K, Sonnenberg A. Integrins control motile strategy through a Rho-cofilin pathway. J CELL BIOL 2005;169 (3):515-526 [PubMed]
2004
Malliri A, van Es S, Huveneers S, Collard JG. The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J BIOL CHEM 2004;279 (29):30092-30098 [PubMed]
2002
van Oort E, de Heer PG, van Leeuwen WA, Derksen NIL, Müller M, Huveneers S, Aalberse RC, van Ree R. Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite. EUR J BIOCHEM 2002;269 (2):671-679[PubMed]